Firming, lifting, and wrinkle reduction have always been central goals in anti-aging aesthetic treatments. However, not everyone is eager to try intensive, high-end energy-based device procedures. So, is there an injectable anti-aging option that’s less “heavyweight” but still convenient and effective? Meet Profhilo, also known as the liquid thread lift.
At the renowned international IMCAS (International Master Course on Aging Science) conference in Paris, a groundbreaking new hyaluronic acid (HA) product—Profhilo—was unveiled to the global medical aesthetics community. This new-generation stabilized HA, free of chemical cross-linkers, opened up a whole new chapter in injectable anti-aging treatments by targeting skin laxity and sagging.
Profhilo, as it’s often referred to, doesn’t have a fixed Chinese translation. It is manufactured by the Italian pharmaceutical company IBSA Farmaceutici Italia. Utilizing their proprietary NAHYCO™ Hybrid Technology, Profhilo is a unique injectable composed of a thermally stabilized hybrid complex of hyaluronic acids—without the use of chemical cross-linking agents. In simple terms, it’s a highly pure injectable treatment designed for firming, lifting, and skin rejuvenation.
This innovative formulation combines 32mg of low molecular weight HA (L-HA: 80–100 KDa) and 32mg of high molecular weight HA (H-HA: 1100–1400 KDa), achieving an unprecedented total concentration of 64mg. Remarkably, this is done without using cross-linking agents like BDDE (1,4-Butanediol Diglycidyl Ether), a common chemical in traditional dermal fillers. Thanks to this, Profhilo has been approved by the U.S. FDA for aesthetic anti-aging use, signifying both its safety and efficacy.
Unlike traditional dermal fillers that target specific areas for volume restoration, Profhilo is an ultra-pure, ultra-high concentration hyaluronic acid product designed to deeply hydrate the skin and trigger the natural production of collagen and elastin. Its unique composition enables the skin to regain elasticity, appearing firmer and more radiant.
What makes Profhilo truly unique is its thermal bonding process, rather than chemical cross-linking. Without BDDE, Profhilo achieves bio-remodeling effects—firming, tightening, hydrating, and even filling fine lines and wrinkles. According to IBSA, Profhilo is 100% pure hyaluronic acid produced via fermentation and contains no additives, making it highly biocompatible and low-risk in side effects. In terms of purity, safety, and resistance to thermal degradation, it is considered among the highest quality HA products worldwide.
Scientific Support: Effects of Profhilo on Skin Remodeling
One study focusing on skin component remodeling found:
-
Fibroblasts (HDF cells) treated with Profhilo showed significantly higher elastin protein expression compared to natural H-HA and L-HA.
-
Profhilo also enhanced the synthesis of collagen types I and III (COLI & COLIII) in fibroblasts at a greater activation rate than native H-HA and L-HA.
-
In keratinocytes (HaCaT cells), Profhilo significantly increased the expression of COLIV and COLVII, also surpassing native H-HA and L-HA in efficacy.
Profhilo is administered using a technique known as BAP (Bio Aesthetic Points)—a five-point injection method that delivers the product into the superficial subcutaneous layer of the face. It diffuses evenly without causing bruising, continually improving the skin’s hydration and luminosity. It also smooths fine lines and wrinkles, refines skin texture, and helps lift sagging skin to restore a youthful appearance.
It is ideal for injection into areas with visible skin laxity, such as the face, cheeks, and jawline. Due to its high cohesivity and safety profile, Profhilo can even be used in traditionally difficult-to-treat areas like the forehead, hands, upper arms, and neck—regions where conventional injectable products often fall short.
Think of Profhilo as a hybrid: it provides the deep hydration and moisture-locking benefits of skin boosters, the regenerative collagen-stimulating effect of biostimulators, and the anti-wrinkle action of botulinum toxin or HA fillers. For skin that is visibly sagging or aging, Profhilo works quietly yet powerfully—producing results that will truly impress.
